Fcγ Receptor-Mediated Inflammation Inhibits Axon Regeneration
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چکیده
منابع مشابه
Fcγ Receptor-Mediated Inflammation Inhibits Axon Regeneration
Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy. We previously reported that disease-relevant anti-glycan autoantibodies inhibited axon regeneration, which echo the clinical association of these antibodies and poor recovery in Guillain-Barré Syndrome. However, the specific molecul...
متن کاملInflammation and axon regeneration.
PURPOSE OF REVIEW The inflammatory response that accompanies neural injury involves multiple cell types and effector molecules with both positive and negative effects. Inflammation is essential for normal regeneration in the peripheral nervous system, and here we review evidence that augmenting inflammation can enhance regeneration in areas of the central nervous system in which it normally doe...
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Peripheral neuropathies are among the most common diseases encountered in clinical neurology. Autoimmunity and inflammation are implicated in a small but important group of peripheral nerve disorders because they are potentially treatable. These include the acute inflammatory neuropathies grouped under Guillain-Barré syndrome (GBS) and the chronic inflammatory demyelinating polyradiculoneuropat...
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Many neurons have limited capacity to regenerate their axons after injury. Neurons in the mammalian central nervous system do not regenerate, and even neurons in the peripheral nervous system often fail to regenerate to their former targets. This failure is likely due in part to pathways that actively restrict regeneration; however, only a few factors that limit regeneration are known. Here, us...
متن کاملRNA ligation in neurons by RtcB inhibits axon regeneration.
Activity of the RNA ligase RtcB has only two known functions: tRNA ligation after intron removal and XBP1 mRNA ligation during activation of the unfolded protein response. Here, we show that RtcB acts in neurons to inhibit axon regeneration after nerve injury. This function of RtcB is independent of its basal activities in tRNA ligation and the unfolded protein response. Furthermore, inhibition...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0088703